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The M glycoprotein is the most abundant envelope protein of SARS-CoV-2. In silico analyses of the M protein of SARS-CoV-2 using Protter demonstrated that it has a triple-helix bundle, and forms a single 3-transmembrane domain. It has been reported that SARS-CoV-2 membrane glycoprotein M may function as a negative regulator of the innate immune response. It is suggested that the M protein interacted with the central adaptor protein MAVS in the innate immune response pathways.
COVID19 Membrane Glycoprotein
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